4,4'-Dimethoxytrityl chlorideke nucleoside e matla le sehlopha sa nucleotide se sireletsang le ho felisa moemeli.
Synonym:DMT-Cl
Nomoro ea CAS:40615-36-9
Thepa
Foromo ea Lik'hemik'hale
Boima ba Molek'hule
Mocheso oa polokelo
Melting Point
Bohloeki
Bokantle
C21H19ClO2
338.82 g/mol
2 ~ 8℃
120-125 ℃
≥98%
Crystalline e pinki
Joaloka likarolo tsa bohlokoa tsa liketane tsa nucleic acid, nucleosides le nucleotide li phetha karolo ea bohlokoa ho fetiseng boitsebiso ba liphatsa tsa lefutso.Leha ho le joalo, ka lebaka la ts'ebetso ea bona ea lik'hemik'hale le ho senyeha habonolo, li-nucleosides le nucleotide li hloka li-reagents tse khethehileng ho li sireletsa nakong ea ho kopanya.DMTCl4' Dimethoxytrityl (DMTCl) ke sehlopha se sebetsang hantle haholo se sireletsang le ho felisa ntho e fetotseng tšireletso ea li-nucleoside le nucleotide nakong ea ho kopanya.
DMTCl ke ntho e sireletsang hydroxyl eo ka boikhethelo e sebetsanang le lihlopha tsa hydroxyl tsa nucleosides le nucleotide nakong ea ho kopanya ho theha sehlopha sa nakoana se sireletsang se thibelang li-nucleoside le nucleotide ho sebetsana le lik'hemik'hale tse ling.Sehlopha sena sa nakoana se sireletsang se tlosoa habonolo ka mor'a hore se kopane, se siea li-nucleoside tse hloekileng kapa li-nucleotide.
Ka lebaka la ts'ebetso ea eona e ntle le ho khetha,DMTCle sebelisoa haholo e le sehlopha se sireletsang le ho felisa moemeli ha ho etsoa DNA, RNA le li-nucleic acid tse ling.E bohlokoa haholo bakeng sa motsoako oa oligonucleotide moo taolo e nepahetseng holim'a boemo ba nucleotide le tatellano e hlokahalang.
Ntle le ho sebetsa joalo ka mosireletsi oa sehlopha le sebolai, DMTCl ke mosireletsi ea matla oa hydroxyl oa li-nucleosides le nucleotide.E sireletsa lihlopha tsa hydroxyl tsa nucleosides le nucleotide ho tsoa ho oxidation, phokotso, le liketso tse ling tse ka li senyang nakong ea synthesis.
Ka kakaretso,DMTCl4 4' dimethoxytritylke sesebelisoa sa bohlokoa bakeng sa ho qaptjoa ha li-nucleosides le nucleotide.Reactivity ea eona e babatsehang, ho khetha le ho feto-fetoha ha maemo ho etsa hore e be sehlopha se loketseng se sireletsang le ho felisa moemeli le moemeli oa tšireletso oa hydroxyl bakeng sa DNA, RNA le tse ling tsa nucleic acid synthesis.Haeba o hloka ts'ireletso ea boleng bo holimo le e tšepahalang ea li-nucleoside le li-nucleotide nakong ea ho kopanya, se shebe hole ho feta DMTCl.
Nako ea poso: Jun-08-2023