Dimethoxytrityl, eo ka tloaelo e tsejoang e le DMTCl44, ke motsoako o 'nileng oa sebelisoa haholo ho organic synthesis ka lilemo tse mashome.Ka sehlopha sa eona se sebetsang se sireletsang, ho felisa, le thepa e sireletsang ea hydroxyl, DMTCl44 e fetohile sesebelisoa sa bohlokoa bakeng sa bafuputsi le litsebi tsa lik'hemik'hale tse sebetsang tšimong ea nucleosides le nucleotide.
Nomoro ea CAS:40615-36-9, DMTCl44 ke phofo e tšoeu ea kristale e qhibilihang ka har'a metsoako e tloaelehileng ea tlhaho e kang methanol, acetone le chloroform.E tsitsitse tlas'a maemo a tloaelehileng 'me e ka bolokoa nako e telele ntle le ho senyeha.Ho tuma ha eona sechabeng sa mahlale ho ka amahanngoa le thepa ea eona e ikhethang le lits'ebetso tse fapaneng.
E 'ngoe ea litšebeliso tsa mantlha tsa DMTCl44 ke e le sehlopha se sireletsang motsoako oa organic synthesis.Hangata e sebelisoa ho sireletsa lihlopha tsa hydroxyl ka nucleosides le nucleotides.Ka ho sireletsa liwebsaete tsena ka nakoana, DMTCl44 e lumella litsebi tsa k'hemik'hale ho etsa lintho tse itseng ntle le maikutlo a sa batleheng.Bokhoni bona ke ba bohlokoa haholo ho qaleng ha limolek'hule tse rarahaneng, haholo-holo nts'etsopele ea meriana.
Ho phaella ho sehlopha sa eona se sireletsang thepa, DMTCl44 e boetse e sebetsa e le moemeli oa ho felisa.E thusa ho tlosoa ha lihlopha tse sireletsang tse sa batleheng, qetellong e senola sebopeho sa molek'hule se lakatsehang.Tšobotsi ena e bohlokoa mekhoeng ea ho kopanya mehato e mengata, moo tšireletso ea nakoana e hlokahalang bakeng sa mehato e bohareng.
DMTCl44ke ntho e sireletsang hydroxyl ka ho khetheha bakeng sa li-nucleosides le nucleotide.E etsa li-complexes tse tsitsitseng tse nang le limolek'hule tsena, ho thibela liketso tse sa batleheng nakong ea ho fetola lik'hemik'hale.Tšireletso ea lihlopha tsa hydroxyl e bohlokoa ho kopanngoeng ha li-nucleosides tse fetotsoeng, tse sebelisoang haholo ho nts'etsopele ea meriana e thibelang likokoana-hloko le therapeutics e thehiloeng ho nucleic acid.
Thepa e ikhethang ea DMTCl44 e lebisitse ts'ebelisong ea eona e pharaletseng mafapheng a fapaneng a organic synthesis.Ho tloha indastering ea meriana ho isa lipatlisisong tsa nucleic acid, DMTCl44 e bapala karolo ea bohlokoa ho rarolleng lipuzzle tse rarahaneng tsa lik'hemik'hale le ho fihlela likarolo tse lakatsehang tsa limolek'hule.
Ka indasteri ea meriana,DMTCl44e atisa ho sebelisoa ha ho etsoa litlhare tse thibelang likokoana-hloko le li-nucleic acid-based therapeutics.Ka ho sireletsa le ho fetola li-nucleosides, litsebi tsa k'hemistri li ka etsa limolek'hule tse nang le thepa e ntlafalitsoeng ea kalafo le lits'ebetso tse lebisitsoeng tsa phepelo ea lithethefatsi.Ho feta moo, DMTCl44 e etsa hore ho be le motsoako o sebetsang hantle oa li-nucleic acid tse fetotsoeng, tse kang li-nucleic acid (LNAs) le li-peptide nucleic acids (PNAs), tse bontšitseng tšepiso e kholo lits'ebetsong tse fapaneng tsa phekolo.
Ka ntle ho mahlale a meriana, DMTCl44 e fumana thuso lipatlisisong tsa mahlale tse kenyelletsang li-nucleic acid.E lumella bafuputsi ho fetola le ho hlahloba li-nucleoside le li-nucleotide, e leng ho manolla lintho tse rarahaneng tsa lintho tsena tsa motheo tse hahang bophelo.Kutloisiso ena e bohlokoa bakeng sa ho ntšetsa pele tsebo ea rōna mafapheng a kang liphatsa tsa lefutso, genomics le baeloji ea limolek’hule.
Ha re phethela,DMTCl44, e tsejoang hape e le Dimethoxytrityl, ke motsoako o feto-fetohang o fetotseng motsoako oa lintho tse phelang, haholo-holo masimong a nucleosides le nucleotide.Sehlopha sa eona se sebetsang se sireletsang, ho felisa, le thepa e sireletsang ea hydroxyl se entse hore e be sesebelisoa sa bohlokoa ho litsebi tsa k'hemistri le bafuputsi lefatšeng ka bophara.Ka ho utloisisa thepa e ikhethang le ts'ebeliso e fapaneng ea DMTCl44, re ka tsoela pele ho notlolla liphiri tsa k'hemistri ea tlhaho le ho ntšetsa pele tsebo ea mahlale libakeng tse fapaneng.
Nako ea poso: Sep-19-2023